Metadoxine antagonizes the lipid peroxidation in liver cells, restoring liver damage resulting horn prolonged alcohol intake and reduces fatty liver in chronic hepatitis.
Viboliv (Metadoxine Tablets and Injection)
International Non- Proprietary Name - Metadoxine
Chemical Name - Pyridoxine L -2- proliclone-5- carboxylate
Composition
Each film-coated tablet contains:
Metadoxine - 500 mg
COLOUR - litanium Dioxide IP
Viboliv Injection
Each ml contains:
Metadoxine - 500 mg
Methylparaben IP – 0.05% w/v
(As preservative)
Water for Injection IP
Mechanism of Action
Metadoxine antagonizes the lipid peroxidation in liver cells, restoring liver damage resulting horn prolonged alcohol intake and reduces fatty liver in chronic hepatitis.
Furthermore Metadoxine acts specifically on the neuro-transmitter systems involved in alcoholic intoxication, increasing the release of GABA and Acetyl Choline.
Metadoxine improves ethanol metabolism, reducing plasma ethanol levels during alcohol intake and improves the cognitive impairment, as well as the main psychological symptoms (aggressiveness, agitation, mood and behavioral disturbances) due to occasional or prolonged alcohol abuse.
Therapeutic Efficacy
Viboliv reduces the stay-time of ethanol in the organism, thus minimizing its toxic effects on cells. Viboliv also protects cell structure and function acting on those biochemical processes which defend them.
Due to these peculiar pharmacological properties, Viboliv reduces detoxification time in acute ethanol intoxication and prevents or reduces the hepatic and neuropsychic consequences of habitual intake of alcohol.
Indications
Treatment of fatty liver due to alcoholism, acute and chronic intoxication of alcohol.
Dosage and Administration
Acute ethanol intoxication
1 - 2 ampoules administered intramuscularly or intravenously.
For other indications:
2 tablets daily, administered orally, or I ampoule daily, administered intramuscularly, or intravenously.
Contraindications
Known hypersensitivity to the preparation.
Caution must be exercised in Parkinsonians treated with L-Dopa, as Viboliv may antagonize the drug's effect.
Use during pregnancy and lactation
Viboliv should not be administered during pregnancy and lactation.
Drug Interactions
Metadoxine may increase the peripheral decarboxylation of levodopa, decreasing its efficacy.
Incompatibility
With iron salts, alkaline solutions, oxidant solutions.
Warnings
Viboliv ampoules contain sodium metabisulfite. This substance may cause allergic reactions and severe asthmatic attacks in sensitive patients, particularly in asthmatics
Storage
Store below 25 c. Protect from light & moisture
Keep out of reach of children.
Presentation
Viboliv Tablet: Strip of 10 tablets.
Viboliv Injection: Ampoule of 5ml
Viboliv (Metadoxine Tablets and Injection)
International Non- Proprietary Name - Metadoxine
Chemical Name - Pyridoxine L -2- proliclone-5- carboxylate
Composition
Each film-coated tablet contains:
Metadoxine - 500 mg
COLOUR - litanium Dioxide IP
Viboliv Injection
Each ml contains:
Metadoxine - 500 mg
Methylparaben IP – 0.05% w/v
(As preservative)
Water for Injection IP
Mechanism of Action
Metadoxine antagonizes the lipid peroxidation in liver cells, restoring liver damage resulting horn prolonged alcohol intake and reduces fatty liver in chronic hepatitis.
Furthermore Metadoxine acts specifically on the neuro-transmitter systems involved in alcoholic intoxication, increasing the release of GABA and Acetyl Choline.
Metadoxine improves ethanol metabolism, reducing plasma ethanol levels during alcohol intake and improves the cognitive impairment, as well as the main psychological symptoms (aggressiveness, agitation, mood and behavioral disturbances) due to occasional or prolonged alcohol abuse.
Therapeutic Efficacy
Viboliv reduces the stay-time of ethanol in the organism, thus minimizing its toxic effects on cells. Viboliv also protects cell structure and function acting on those biochemical processes which defend them.
Due to these peculiar pharmacological properties, Viboliv reduces detoxification time in acute ethanol intoxication and prevents or reduces the hepatic and neuropsychic consequences of habitual intake of alcohol.
Indications
Treatment of fatty liver due to alcoholism, acute and chronic intoxication of alcohol.
Dosage and Administration
Acute ethanol intoxication
1 - 2 ampoules administered intramuscularly or intravenously.
For other indications:
2 tablets daily, administered orally, or I ampoule daily, administered intramuscularly, or intravenously.
Contraindications
Known hypersensitivity to the preparation.
Caution must be exercised in Parkinsonians treated with L-Dopa, as Viboliv may antagonize the drug's effect.
Use during pregnancy and lactation
Viboliv should not be administered during pregnancy and lactation.
Drug Interactions
Metadoxine may increase the peripheral decarboxylation of levodopa, decreasing its efficacy.
Incompatibility
With iron salts, alkaline solutions, oxidant solutions.
Warnings
Viboliv ampoules contain sodium metabisulfite. This substance may cause allergic reactions and severe asthmatic attacks in sensitive patients, particularly in asthmatics
Storage
Store below 25 c. Protect from light & moisture
Keep out of reach of children.
Presentation
Viboliv Tablet: Strip of 10 tablets.
Viboliv Injection: Ampoule of 5ml
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